Additional Information
| Product Name: | GNE-6776 |
|---|---|
| Also Known As: | 6′-amino-4′-ethyl-5′-(4-hydroxyphenyl)-N-methyl-[3,3′-bipyridine]-6-carboxamide, Cas# 2009273-71-4 |
| Catalog No.: | F4112-25 |
| Size: | 25 mg |
| Molecular Weight: | 348.41 g/mol |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| Quality Assurance: | >98% by HPLC and NMR |
| Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
| PDF Data Sheet: | PDF Datasheet, MSDS |
| NCBI RefSeq: | N/A |
| Image(s): | No |
| Shipping Method: | Room temperature shipping |
| References: | 1. Kategaya L, et al. (2017) Nature, 550(7677):534-538. |
Details
GNE-6776 is a selective USP7 inhibitor that non-covalently targets USP7 (IC50 value at 1.34 μM) to attenuate ubiquitin binding, thus inhibiting deubiquitinase activity. It induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds including PIM kinase inhibitors.
