Geldanamycin

Geldanamycin is a selective inhibitor of heat shock protein 90 (Hsp90) and its parplog GRP94. Binds to the ATP site of Hsp90/GRP94 (Kd = 1.2 μM) and inhibits their chaperone activity, which affects numerous downstream client proteins with roles in gene expression, cell proliferation, apoptosis and angiogenesis.


Solubility: > 20 mg/ml in DMSO

Working Concentration: 1 nM - 10 uM

Additional Information

Product Name: Geldanamycin
Also Known As: HSP90 inhibitor, NSC122750
Catalog No.: F6102-5
Size: 5 mg
CAS: 30562-34-6
Formula: C29H40N2O9
Molecular Weight: 560.6 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Whitesell L, et al (1994) Proc Natl Acad Sci USA, 91, 8324.

Details

Geldanamycin is a selective inhibitor of heat shock protein 90 (Hsp90) and its parplog GRP94. Binds to the ATP site of Hsp90/GRP94 (Kd = 1.2 μM) and inhibits their chaperone activity, which affects numerous downstream client proteins with roles in gene expression, cell proliferation, apoptosis and angiogenesis.

Solubility: > 20 mg/ml in DMSO
Working Concentration: 1 nM - 10 uM