Additional Information
Product Name: | GDC-0068 (RG7440, Ipatasertib) |
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Also Known As: | Ipatasertib, (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one |
Catalog No.: | F6171 |
Size: | 25 mg |
CAS: | 1001264-89-6 |
Formula: | C24H32ClN5O2 |
Molecular Weight: | 458 g/mol |
Form: | Powder |
Quality Assurance: | >98% by HPLC and NMR |
Source: | Synthetic |
Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
PDF Data Sheet: | Download PDF datasheet, MSDS |
Image(s): | N/A |
Shipping Method: | Room temperature shipping |
References: | Blake JF, et al. (2012) J Med Chem. 55(18):8110-27. |
Details
GDC-0068 (RG7440 or Ipatasertib) is a novel, ATP-competitive Akt1/2/3 inhibitor with IC50 values of 5 nM, 18 nM and 8 nM, respectively. GDC-0068 selectively inhibits cell cycle progression and viability of cancer cell lines driven by PI3K/Akt signaling pathway, including those with defects of the tumor suppressor PTEN, oncogenic mutations in PIK3CA, and amplification of HER2. GDC-0068 blocks the phosphorylation of multiple downstream targets of Akt in human cancer cell lines.
Solubility:
> 20 mg/ml in DMSO
Solubility:
> 20 mg/ml in DMSO