Doxorubicin HCl

Doxorubicin is an anthracycline antitumor antibiotic that Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Doxorubicin binds covalently to DNA and inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1.

Additional Information

Product Name: Doxorubicin HCl
Also Known As: 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
Catalog No.: F8111
Size: 25 mg
Molecular Weight: 579.99 g/mol
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: >99% by HPLC and NMR
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
PDF Data Sheet: PDF Datasheet, MSDS
NCBI RefSeq: N/A
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Taatjes DJ, et al (1996) J. Med. Chem. 39: 4135-4138.
2. Pourquier P, et al. (1998) Biochem. Pharmacol. 55: 1963-1971.
3. Zeman SM, et al. (1998) Proc. Natl. Acad. Sci. U.S.A. 95: 11561-11565.
4. Sun W, et al. (2009 ) Cancer Res. 69(10): 4294-4300.
5. Granados-Principal S, et al. (2010) Food Chem Toxicol 48(6): 1425-1438.

Details

Doxorubicin is an anthracycline antitumor antibiotic that Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Doxorubicin binds covalently to DNA and inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1.

How to use
Doxorubicin hydrochloride was used at 1-1,000 nM in various cell-based assays.