DBeQ

A potent, reversible, cell permeable and specific inhibitor of ATPase of p97 (also called valosin-containing protein (VCP)) with IC50 of 1.5 μM. DBeQ inhibits both ubiquitin-dependent and autophagic protein degradation pathways and rapidly induces caspases -3 and -7 activity and apoptosis.

Additional Information

Product Name: DBeQ
Also Known As: N², N⁴-Dibenzylquinazoline-2,4-diamine; CAS# 177355-84-9; C₂₂H₂₀N₄
Catalog No.: F1420
Size: 5 mg
Molecular Weight: 340.42 Da
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: ≥ 98% by HPLC
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
PDF Data Sheet: PDF Datasheet, MSDS
NCBI RefSeq: N/A
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Chou TF, et al. (2011) Proc Natl Acad Sci U S A, 108(12), 4834-4839.

2. Chou TF, et al. (2011) Autophagy, 7(9), 1091-1092.


Details

A potent, reversible, cell permeable and specific inhibitor of ATPase of p97 (also called valosin-containing protein (VCP)) with IC50 of 1.5 μM. DBeQ inhibits both ubiquitin-dependent and autophagic protein degradation pathways and rapidly induces caspases -3 and -7 activity and apoptosis.