CHIR-99021 HCl

CHIR-99021 (CT99021) is an inhibitor of GSK-3α/β with IC50 of 10 nM/6.7 nM, respectively. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells.

Additional Information

Product Name: CHIR-99021 HCl
Also Known As: 6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino)ethylamino)nicotinonitrile hydrochloride
Catalog No.: F6190
Size: 5 mg
CAS: 252917-06-9
Formula: C22H18Cl2N8.HCl
Molecular Weight: 501.8 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: Ring DB, et al. (2003) Diabetes 52(3), 588-595.

Details

CHIR-99021 (CT99021) is an inhibitor of GSK-3α/β with IC50 of 10 nM/6.7 nM, respectively. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells.

Solubility:
> 20 mg/ml in DMSO