CB-5083

CB-5083 is a potent ATPase activity inhibitor of p97. p97 (also called VCP) is an AAA-ATPase that plays an important role in various cellular functions including ER-associated degradation. CB-5803 induces significant unfolded protein response and apoptosis of various cancer cells. P97 is orally active and currently in clinical trials for relapsed multiple myeloma.

Additional Information

Product Name: CB-5083
Also Known As: CAS# 1542705-92-9
Catalog No.: F1425-25
Size: 25 mg
Molecular Weight: 413.47 g/mol
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: >98% by HPLC and NMR
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
NCBI RefSeq: N/A
Image(s): No
Shipping Method: Room temperature shipping
References: 1. Anderson D J, et al. (2015) Cancer Cell., 28, 653
2. Zhou H J, et al. (2015) J. Med. Chem., 58, 9480

Details

CB-5083 is a potent ATPase activity inhibitor of p97. p97 (also called VCP) is an AAA-ATPase that plays an important role in various cellular functions including ER-associated degradation. CB-5803 induces significant unfolded protein response and apoptosis of various cancer cells. P97 is orally active and currently in clinical trials for relapsed multiple myeloma.