CAL-101 (Idelalisib, GS-1101)

CAL-101 (idelalisib or GS-1101) is a potent inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with IC50 of 2.5 nM in cell-free assays. CAL-101 decreases pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM.

Additional Information

Product Name: CAL-101 (Idelalisib, GS-1101)
Also Known As: (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
Catalog No.: F6181
Size: 25 mg
CAS: 870281-82-6
Formula: C22H18FN7O
Molecular Weight: 415.42 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: Lannutti BJ, et al. (2011) Blood, 117(2), 591-594.

Details

CAL-101 (idelalisib or GS-1101) is a potent inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with IC50 of 2.5 nM in cell-free assays. CAL-101 decreases pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM.

Solubility:
> 20 mg/ml in DMSO