BX795

BX-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1), as well as other kinases including TANK-binding kinase 1 (TBK1), Aurora B and IkB kinase ε (IKKε). BX-795 prevents TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β.

Additional Information

Product Name: BX795
Also Known As: N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Catalog No.: F6150
Size: 5 mg
CAS: 702675-74-9
Formula: C23H26IN7O2S
Molecular Weight: 591.47 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: Feldman RI, et al. (2005) J.Biol.Chem. 280 19867.

Details

BX-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1), as well as other kinases including TANK-binding kinase 1 (TBK1), Aurora B and IkB kinase ε (IKKε). BX-795 prevents TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β.

Solubility:
> 20 mg/ml in DMSO