Bardoxolone Methyl (RTA402)

Bardoxolone methyl (RTA402) is a potent Nrf2 transcription factor activator by targeting KEAP1 to prevent Nrf2 ubiquitination and degradation. It exhibits potent antioxidative and anti-inflammatory activities, currently under phase III clinical trials for multiple chronic kidney diseases. It also inhibits NFkappaB-mediated transcription.

Additional Information

Product Name: Bardoxolone Methyl (RTA402)
Also Known As: RTA402, CDDO-methyl ester
Catalog No.: F5250-10
Size: 10 mg
CAS: 218600-53-4
Formula: C32H43NO4
Molecular Weight: 505.69 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1.Yates MS., et al. (2007) Mol Cancer Ther, 6, 154.
2. Wu J., et al. (2014) Toxicology, 318, 22.

Details

Bardoxolone methyl (RTA402) is a potent Nrf2 transcription factor activator by targeting KEAP1 to prevent Nrf2 ubiquitination and degradation. It exhibits potent antioxidative and anti-inflammatory activities, currently under phase III clinical trials for multiple chronic kidney diseases. It also inhibits NFkappaB-mediated transcription.