AZD6738

AZD6738 is a potent inhibitor of ATR kinase. It potentiates the cytotoxicity of cisplatin and gemcitabine in non-small cell lung cancer (NSCLC) cell lines with intact ATM kinase signaling, and potently synergizes with cisplatin in ATM-deficient NSCLC cells.

Additional Information

Product Name: AZD6738
Also Known As: 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine
Catalog No.: F8140
Size: 5 mg
CAS: 1352226-88-0
Formula: C20H24N6O2S
Molecular Weight: 412.51 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: Vendetti FP, et al. (2015) Oncotarget. Oct 27.

Details

AZD6738 is a potent inhibitor of ATR kinase. It potentiates the cytotoxicity of cisplatin and gemcitabine in non-small cell lung cancer (NSCLC) cell lines with intact ATM kinase signaling, and potently synergizes with cisplatin in ATM-deficient NSCLC cells.

Solubility:
20 mg/ml in DMSO