Additional Information
Product Name: | AZD6738 |
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Also Known As: | 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine |
Catalog No.: | F8141 |
Size: | 25 mg |
CAS: | 1352226-88-0 |
Formula: | C20H24N6O2S |
Molecular Weight: | 412.51 g/mol |
Form: | Powder |
Quality Assurance: | >98% by HPLC and NMR |
Source: | Synthetic |
Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh |
PDF Data Sheet: | Download PDF datasheet, MSDS |
Image(s): | N/A |
Shipping Method: | Room temperature shipping |
References: | Vendetti FP, et al. (2015) Oncotarget. Oct 27. |
Details
AZD6738 is a potent inhibitor of ATR kinase. It potentiates the cytotoxicity of cisplatin and gemcitabine in non-small cell lung cancer (NSCLC) cell lines with intact ATM kinase signaling, and potently synergizes with cisplatin in ATM-deficient NSCLC cells.
Solubility:
20 mg/ml in DMSO
Solubility:
20 mg/ml in DMSO