AZ1

AZ1 is a selective and non-competitive Inhibitor of both deubiquitinase USP25 and USP28 with IC50s of 0.62 μM and 0.7 μM, respectively, when assayed in vitro using Ub-rhodamine110 as the substrate . AZ1 reduces cell viability of a range of cancer cell lines with an EC50 around 20 μM.

Additional Information

Product Name: AZ1
Also Known As: USP25/USP28 inhibitor AZ1
Catalog No.: F4125-25
Size: 25 mg
CAS: 2165322-94-9
Formula: C17H16BrF4NO2
Molecular Weight: 422.21 g/mol
Form: Powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light.
PDF Data Sheet: Download PDF datasheet, MSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: 1. Wrigley JD., et al (2017) SCS Chem Bio., 15, 3113.

Details

AZ1 is a selective and non-competitive Inhibitor of both deubiquitinase USP25 and USP28 with IC50s of 0.62 μM and 0.7 μM, respectively, when assayed in vitro using Ub-rhodamine110 as the substrate . AZ1 reduces cell viability of a range of cancer cell lines with an EC50 around 20 μM.