AT-406 (SM-406)

AT-406 (also called SM-406) is a potent Smac mimetic that inhibits the ubiquitin ligase activity of inhibitors of apoptosis proteins XIAP, cIAP1 and cIAP2 with Ki values of 66.4, 1.9 and 5.1 nM, respectively. AT-406 induces apoptosis of various human cancer cell lines.

Additional Information

Product Name: AT-406 (SM-406)
Also Known As: CAS# 1071992-99-8
Catalog No.: F7170-5
Size: 5 mg
Molecular Weight: 561.71 g/mol
Species: N/A
Source: Synthetic
Stock: Powder
Concentration: N/A
Quality Assurance: >98% by HPLC and NMR
Storage: Eligible for room temperature shipping.Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
NCBI RefSeq: N/A
Image(s): No
Shipping Method: Room temperature shipping
References: 1. Cai Q., et al. (2011) J. Med. Chem. 54, 2714
2. Brunckhorst M. K., et al. (2012) Cancer Biol. Ther., 13, 804

Details

AT-406 (also called SM-406) is a potent Smac mimetic that inhibits the ubiquitin ligase activity of inhibitors of apoptosis proteins XIAP, cIAP1 and cIAP2 with Ki values of 66.4, 1.9 and 5.1 nM, respectively. AT-406 induces apoptosis of various human cancer cell lines.