Additional Information
Product Name: | AT-406 (SM-406) |
---|---|
Also Known As: | CAS# 1071992-99-8 |
Catalog No.: | F7170-5 |
Size: | 5 mg |
Molecular Weight: | 561.71 g/mol |
Species: | N/A |
Source: | Synthetic |
Stock: | Powder |
Concentration: | N/A |
Quality Assurance: | >98% by HPLC and NMR |
Storage: | Eligible for room temperature shipping.Store at -20°C upon receiving; protect from air and ligh |
PDF Data Sheet: | Download PDF datasheet, MSDS |
NCBI RefSeq: | N/A |
Image(s): | No |
Shipping Method: | Room temperature shipping |
References: | 1. Cai Q., et al. (2011) J. Med. Chem. 54, 2714 2. Brunckhorst M. K., et al. (2012) Cancer Biol. Ther., 13, 804 |
Details
AT-406 (also called SM-406) is a potent Smac mimetic that inhibits the ubiquitin ligase activity of inhibitors of apoptosis proteins XIAP, cIAP1 and cIAP2 with Ki values of 66.4, 1.9 and 5.1 nM, respectively. AT-406 induces apoptosis of various human cancer cell lines.