GST-NEDD4

NEDD4 (neural precursor cell expressed developmentally down-regulated protein 4) is a widely expressed HECT domain-containing E3 ubiquitin ligase. NEDD4 ubiquitinates a few membrane proteins, including IGF-1R and PTEN, by which it regulates signal transduction.


Additional Information

Product Name: GST-NEDD4
Also Known As: NEDD4-1; neural precursor cell expressed developmentally down-regulated protein 4
Catalog No.: K1420
Size: 50 µg
Molecular Weight: 104 kDa (no GST tag)
Species: Human
Source: Bacterial recombinant
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: ~90% by SDS-PAGE, see datasheet for gel image
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF Datasheet
NCBI RefSeq: NM_006154.3
Image(s): (Click image to enlarge)

Coomassie-stained SDS-PAGE
Lane 1: Molecular weight markers
Lane 2: 5 µg purified GST-UbE3A (E6AP)
Shipping Method: Dry ice shipping
References: 1. Cao XR, et al., NEDD4 controls animal growth by regulating IGF-1 signaling. Sci Signal. 1 (38): ra5. 2. Wang X, et al., NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 128, 129.

Details

NEDD4 (neural precursor cell expressed developmentally down-regulated protein 4) is a widely expressed HECT domain-containing E3 ubiquitin ligase. NEDD4 ubiquitinates a few membrane proteins, including IGF-1R and PTEN, by which it regulates signal transduction.

Images:
(Click image to enlarge)