Additional Information
| Product Name: | 6xHis-UbE2E1 (UbcH6) | ||
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| Also Known As: | UBCH6 | ||
| Catalog No.: | C1800 | ||
| Size: | 25 µg | ||
| Molecular Weight: | 21.4 kDa | ||
| Species: | Human | ||
| Source: | Bacterial recombinant | ||
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol | ||
| Concentration: | See tube label | ||
| Quality Assurance: | ~90% by SDS-PAGE, see datasheet for gel image | ||
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles | ||
| PDF Data Sheet: | PDF Datasheet， MSDS | ||
| NCBI RefSeq: | NM_003341 | ||
| Image(s): | (Click image to enlarge)
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| Shipping Method: | Dry ice shipping | ||
| References: | 1. Nuber U, et al. (1996) J Biol Chem 271(5), 2795 – 2800. 2. Yamada HY, et al. (2006) Oncogene 25(9), 1330 – 1339. 3. Espinosa A, et al. (2008) Exp Cell Res 314, 3605–3613. 4. Espinosa A, et al. (2009) J Exp Med 206, 1661–1671. |
Details
UbE2E1 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. UbE2E1 was found to locate in the nucleus. It, along with UbE2D1, is known to complex with the E3 ligase Ro52 to ubiquitinate interferon regulatory transcription factors IRF3 and IRF8. UbE2E1 can also complex with a Ub ligase called RING105 to ubiquitinate a tumor suppressor known as tumor – suppressing subchromosomal transferable fragment cDNA (TSSC5).
Images:
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified 6xHis-Ube2E1 (UbcH6) |
