USP7

USP7 is a cysteine protease, belongs to the family of ubiquitin-specific proteases. USP7 was first discovered as a binding enzyme to the Herpes simplex viral protein. Studies have shown that USP7 could deubiquitinate the autoubiquitination of an E3
ligase called HDM2 that promotes ubiquitination and subsequent degradation of p53. The USP7/HDM2/p53 interaction results in higher protein levels of HDM2 and lower levels of p53. Because of its apparent role in different types of pathologies, including lung and liver cancer, it has become a possible target for drug therapies.

Additional Information

Product Name: USP7
Also Known As: TEF1; HAUSP
Catalog No.: H5700
Size: 25 µg
Molecular Weight: 128.3 kDa
Species: Human
Source: Sf9 insect cells
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: ~90% by SDS-PAGE, see datasheet for gel image
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: NM_003470
Image(s): No
Shipping Method: Dry ice shipping
References: 1. Everett RD, et al. (1997) EMBO J 16(7), 1519 – 1530.
2. Li M, et al. (2004) Mol Cell 26(13), 879 – 886.
3. Cummins JM, et al (2004) Nature 428(6982), 1 p following 486.
4. Nicholson B, et al. (2011) Cell Biochem Biophys 60(1 – 2), 61 – 68.

Details

USP7 is a cysteine protease, belongs to the family of ubiquitin-specific proteases. USP7 was first discovered as a binding enzyme to the Herpes simplex viral protein. Studies have shown that USP7 could deubiquitinate the autoubiquitination of an E3 ligase called HDM2 that promotes ubiquitination and subsequent degradation of p53. The USP7/HDM2/p53 interaction results in higher protein levels of HDM2 and lower levels of p53. Because of its apparent role in different types of pathologies, including lung and liver cancer, it has become a possible target for drug therapies.