UCHL1

Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. UCHL1 is one of the four members of the ubiquitin C-terminal hydrolase (UCH) family. It is thought to be mainly involved in cleaving proubiquitin proteins into monomeric ubiquitin.

Additional Information

Product Name: UCHL1
Also Known As: PARK5; PGP95; PGP9.5; Uch-L1; PGP 9.5
Catalog No.: H1100
Size: 25 µg
Molecular Weight: 24.8 kDa
Species: Human
Source: Bacterial recombinant
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: ~95% by SDS-PAGE, see datasheet for gel image
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: NM_004181
Image(s): No
Shipping Method: Dry ice shipping
References: 1. Pickart CM, et al. (1985) J Biol Chem 260(13), 7903 – 7910.
2. Wilkinson KD (1997) FASEB J 11(14), 1245 – 1256.
3. Larsen CN, et al. (1998) Biochemistry 37(10), 3358 – 3368.
4. Reyes-Turcu FE, et al. (2009) Annu Rev Biochem 78, 363 – 397.

Details

Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. UCHL1 is one of the four members of the ubiquitin C-terminal hydrolase (UCH) family. It is thought to be mainly involved in cleaving proubiquitin proteins into monomeric ubiquitin.