MINDY-1

MINDY-1 (FAM63A) is a deubiquitinase that contains a tandem motif interacting with ubiquitin (MIU) that selectively binds lysine 48-linked polyubiquitin. MINDY-1 prefers to cleave lysine 48-linked long polyubiquitin chains.

Additional Information

Product Name: MINDY-1
Also Known As: MINDY1, FAM63A
Catalog No.: H8900
Size: 25 µg
Molecular Weight: 51.8 kDa
Species: Human
Source: E. coli
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: >90% by SDS-PAGE, see datasheet for gel image
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: NM_001319998.1
Image(s): H8900 image

A. Coomassie stained SDS-PAGE of 5 ug Mindy-1. B. Deubiquitination of 5 ug K48 polyUb chain mix or K63 polyUb chain mix by 0.5 uM Mindy-1 in 1X DUB buffer II. Reactions were stopped after 2h incubation.
Shipping Method: Dry ice shipping
References: 1. Kristariyanto YA.,et al. (2017) EMBO Report 18, 392.
2. Rehman SAA., et al. (2016) Mol. Cell 63, 143.

Details

MINDY-1 (FAM63A) is a deubiquitinase that contains a tandem motif interacting with ubiquitin (MIU) that selectively binds lysine 48-linked polyubiquitin. MINDY-1 prefers to cleave lysine 48-linked long polyubiquitin chains.