GST-USP9X(catalytic domain)

USP9X belongs to the ubiquitin-specific protease (USP) family. USP9X has been found to deubiqitinate more than a dozen of substrates including mcl1, survivin, SMAD4, SMN and Itch. USP9X is located on the X chromosome, but it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Also, Usp9X is unregulated in various cancers. The catalytic domain contains the region from amino acid 1531 to amino acid 1972.

Additional Information

Product Name: GST-USP9X(catalytic domain)
Also Known As: AXAM2; SMT3IP2
Catalog No.: H5911
Size: 100 µg
Molecular Weight: 51 kDa
Species: Human
Source: Bacterial recombinant
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: ~ 80% by SDS-PAGE, see datasheet for gel image
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: NM_021627.2
Image(s): (Click image to enlarge)

Coomassie-stained SDS-PAGE
Lane 1: Molecular weight markers
Lane 2: 5 µg purified GST-USPX (catalytic domain)
Shipping Method: Dry ice shipping
References: Homan CC, et al. (2014) Am J Hum Genet. 94(3):470-8.

Details

USP9X belongs to the ubiquitin-specific protease (USP) family. USP9X has been found to deubiqitinate more than a dozen of substrates including mcl1, survivin, SMAD4, SMN and Itch. USP9X is located on the X chromosome, but it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Also, Usp9X is unregulated in various cancers. The catalytic domain contains the region from amino acid 1531 to amino acid 1972.

Images:
(Click image to enlarge)

Coomassie-stained SDS-PAGE
Lane 1: Molecular weight markers
Lane 2: 5 µg purified GST-USPX (catalytic domain)