GST-USP4

Usp4 is a member of the ubiquitin-specific protease family of deubiquitinating enzyme. A number of substrates of Usp4 have been identified, including TRIM21, TRAF2, TRAF6, RIG-1, RIP1, PDK1, TAK1 and etc. Usp4-mediated deubiquitination was found to regulate several signaling pathways, including the AKT signaling, RIG-1-mediated antiviral response, TNFα-induced signaling, and the Wnt signaling.

Additional Information

Product Name: GST-USP4
Also Known As: UNP; Unph
Catalog No.: H5410
Size: 50 µg
Molecular Weight: 108.6 kDa
Species: Human
Source: Bacterial recombinant
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: ~ 75% by SDS-PAGE, see datasheet for gel image
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: NM_003363.3
Image(s):

Images:
(Click image to enlarge)

Coomassie-stained SDS-PAGE
Lane 1: Molecular weight markers
Lane 2: 5 µg purified GST-USP4
Shipping Method: Dry ice shipping
References: 1. Wang L, et al. (2013) J Virol. 87(8):4507-15.
2. Zhang L, et al. (2012) Nat Cell Biol. 14(7):717-26.
3. Xiao N, et al. (2012) Biochem J. 441(3):979-86.

Details

Usp4 is a member of the ubiquitin-specific protease family of deubiquitinating enzyme. A number of substrates of Usp4 have been identified, including TRIM21, TRAF2, TRAF6, RIG-1, RIP1, PDK1, TAK1 and etc. Usp4-mediated deubiquitination was found to regulate several signaling pathways, including the AKT signaling, RIG-1-mediated antiviral response, TNFα-induced signaling, and the Wnt signaling.

Images:
(Click image to enlarge)

Coomassie-stained SDS-PAGE
Lane 1: Molecular weight markers
Lane 2: 5 µg purified GST-USP4