OTB2; OTU2; C14orf137

Additional Information

Product Name: GST-OTUB2
Also Known As: No
Catalog No.: H3110
Size: 25 µg
Molecular Weight: 27.2 kDa
Species: Human
Source: Bacterial recombinant
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: ~95% by SDS-PAGE, see datasheet for gel image
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: NM_023112
Image(s): No
Shipping Method: Dry ice shipping
References: 1. Balakirev MY, et al. (2003) EMBO Rep 4(5), 517 – 522.

2. Reyes-Turcu FE, et al. (2009) Annu Rev Biochem 78, 363 – 397.

3. Li S, et al. (2010) J Biol Chem 285(7), 4291 – 4297.


Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB2 is a member of the ovarian tumor domain family. Not much is known about the biological function of this enzyme, but it may deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.