6xHis-Uch37

Uch37 is one of the deubiquitinating enzymes of the human 26S proteasome, belongs to the Ub C-terminal hydrolases. Uch37 was found to bind both Adrm1 and S5a subunits of the 26S proteasome. Uch37 likely contributes to the Ub chain trimming activity of the 26S proteasome that shortens a polyUb chain from the distal end of the chain. Currently, how Uch37 is activated on the proteasome is not known.

Additional Information

Product Name: 6xHis-Uch37
Also Known As: UCHL5;UCH37; CGI-70; INO80R; UCH-L5
Catalog No.: A3501
Size: 100 µg
Molecular Weight: 37.6 kDa
Species: Human
Source: Bacterial recombinant
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: ~95% by SDS-PAGE, see datasheet for gel image
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: NM_015984
Image(s): No
Shipping Method: Dry ice shipping
References: 1. Verma R, et al. (2000) Mol Biol Cell 11(10), 3425 – 3439.
2. Koulich E, et al. (2007) Mol Biol Cell, 19(3) 1072 – 1082.
3. Husnjak K, et al. (2008) Nature 453, 481 – 488.
4. Lee BH, et al. (2010) Nature 467, 179 – 184.

Details

Uch37 is one of the deubiquitinating enzymes of the human 26S proteasome, belongs to the Ub C-terminal hydrolases. Uch37 was found to bind both Adrm1 and S5a subunits of the 26S proteasome. Uch37 likely contributes to the Ub chain trimming activity of the 26S proteasome that shortens a polyUb chain from the distal end of the chain. Currently, how Uch37 is activated on the proteasome is not known.