Additional Information
| Product Name: | 6xHis-SENP8 | ||
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| Also Known As: | DEN1; NEDP1; PRSC2 | ||
| Catalog No.: | H9820 | ||
| Size: | 25 µg | ||
| Molecular Weight: | 24.1 kDa | ||
| Species: | Human | ||
| Source: | Bacterial recombinant | ||
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol | ||
| Concentration: | See tube label | ||
| Quality Assurance: | > 95% by SDS-PAGE, see datasheet for gel image | ||
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles | ||
| PDF Data Sheet: | PDF Datasheet， MSDS | ||
| NCBI RefSeq: | NM_001166340.1 | ||
| Image(s): | (Click image to enlarge)
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| Shipping Method: | Dry ice shipping | ||
| References: | 1. Gan-Erdene T, et al. (2003) J Biol Chem. 278(31):28892-900. 2. Mendoza HM, et al. (2003) J Biol Chem. 278(28):25637-43. |
Details
Neural precursor cell expressed developmentally downregulated 8 (Nedd8) is a ubiquitin-like protein. Nedd8 can be conjugated on culin proteins and this modification plays a key role in activation of culin-based E3 ubiquitin ligases. SENP8 (also called NEDP1) is a cystein protease that specifically cleaves the Nedd8 precursor to generate mature Nedd8 and deconjugates neddylated proteins including culins and p53.
Images:
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified 6xHis-SENP8 |
