Additional Information
| Product Name: | 6xHis-OTULIN | ||
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| Also Known As: | GUM; FAM105B | ||
| Catalog No.: | H4020 | ||
| Size: | 50 µg | ||
| Molecular Weight: | 40.3 kDa | ||
| Species: | Human | ||
| Source: | Bacterial recombinant | ||
| Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol | ||
| Concentration: | See tube label | ||
| Quality Assurance: | ~ 90% by SDS-PAGE | ||
| Storage: | Store at -80°C; avoid multiple freeze-thaw cycles | ||
| PDF Data Sheet: | PDF Datasheet， MSDS | ||
| NCBI RefSeq: | NM_032663.4 | ||
| Image(s): | Images:
(Click image to enlarge)
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| Shipping Method: | Dry ice shipping | ||
| References: | 1. Tzvetkov N, et al. (2007) Biol. Chem. 388:973-978 2. Li F, et al. (2002) J. Biol. Chem. 277:45004-45012 3. Winborn BJ, et al. (2008) J Biol Chem. 26;283(39):26436-43 |
Details
OTULIN is a deubiquitinating enzyme that specifically cleaves linear polyubiquitin chains. It associates with the LUBAC ubiquitin ligase complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains. OTULIN functions as a regulator of angiogenesis and innate immune response.
Images:
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified 6xHis-OTULIN |
