UMI-77

UMI-77 is a selective Mcl-1 inhibitor by binding of the BH3-binding groove of Mcl-1, by which it blocks the interactions of Bax/Mcl-1 and Bak/Mcl-1. UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induces apoptosis of various pancreatic cancer cell lines.

Additional Information

Product Name: UMI-77
Also Known As: 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid
Catalog No.: F7150
Size: 5 mg
CAS: 518303-20-3
Formula: C18H14BrNO5S2
Molecular Weight: 468.34 g/mol
Form: Lyophilized powder
Quality Assurance: >98% by HPLC and NMR
Source: Synthetic
Storage: Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and ligh
PDF Data Sheet: Download PDF datasheetMSDS
Image(s): N/A
Shipping Method: Room temperature shipping
References: Abulwerdi F, et al. (2014) Mol Cancer Ther. 13(3), 565-575.

Details

UMI-77 is a selective Mcl-1 inhibitor by binding of the BH3-binding groove of Mcl-1, by which it blocks the interactions of Bax/Mcl-1 and Bak/Mcl-1. UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induces apoptosis of various pancreatic cancer cell lines.

Solubility:
20 mg/ml in DMSO

Working Condition:
100 μM in cell culture assays