Additional Information
Product Name: | PAC-1 |
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Also Known As: | N/A |
Catalog No.: | F7131 |
Size: | 25 mg |
CAS: | 315183-21-2 |
Formula: | C23H28N4O2 |
Molecular Weight: | 392.49 g/mol |
Form: | Powder |
Quality Assurance: | >98% by HPLC and NMR |
Source: | Synthetic |
Storage: | Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light |
PDF Data Sheet: | Download PDF datasheet, MSDS |
Image(s): | N/A |
Shipping Method: | Room temperature shipping |
References: | 1. Putt et al. (2006) Nat.Chem.Biol. 2 543. 2. Peterson et al. (2009) J.Med.Chem. 52 5721. |
Details
PAC-1 is a caspase-3 activator. It promotes cleavage of procaspase-3 to produce caspase-3 (EC50 = 0.33 μM). It also converts procaspase-7 to caspase-7 at higher dose (EC50 = 4.5 μM). By induction of caspase-3 and 7, PAC-1 can induce apoptosis in both cancerous cells and non-cancerous cells, but more efficiently for cancerous cells.