Additional Information
Product Name: | GST-Ataxin3(Q22) | ||
---|---|---|---|
Also Known As: | ATXN3; AT3; JOS; MJD; ATX3; MJD1; SCA3 | ||
Catalog No.: | H1610 | ||
Size: | 50 µg | ||
Molecular Weight: | 41.2 kDa | ||
Species: | Human | ||
Source: | Bacterial recombinant | ||
Stock: | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol | ||
Concentration: | See tube label | ||
Quality Assurance: | ~ 90% by SDS-PAGE | ||
Storage: | Store at -80°C; avoid multiple freeze-thaw cycles | ||
PDF Data Sheet: | PDF Datasheet, MSDS | ||
NCBI RefSeq: | NM_004993.5 | ||
Image(s): | Images:
(Click image to enlarge)
|
||
Shipping Method: | Dry ice shipping | ||
References: | 1. Tzvetkov N, et al. (2007) Biol. Chem. 388:973-978 2. Li F, et al. (2002) J. Biol. Chem. 277:45004-45012 3. Winborn BJ, et al. (2008) J Biol Chem. 26;283(39):26436-43 |
Details
Ataxin3 is a Machado-Josephine domain-containing deubiquitinating enzyme. Machado–Joseph disease (MJD) is a neurodegenerative disorder caused by polyQ expansion in ataxin-3. Ataxin3 is involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates.
Images:
(Click image to enlarge)
Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified GST-Ataxin3(Q22) |