GST-Ataxin3(Q22)

Ataxin3 is a Machado-Josephine domain-containing deubiquitinating enzyme. Machado–Joseph disease (MJD) is a neurodegenerative disorder caused by polyQ expansion in ataxin-3. Ataxin3 is involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates.

Additional Information

Product Name: GST-Ataxin3(Q22)
Also Known As: ATXN3; AT3; JOS; MJD; ATX3; MJD1; SCA3
Catalog No.: H1610
Size: 50 µg
Molecular Weight: 41.2 kDa
Species: Human
Source: Bacterial recombinant
Stock: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Concentration: See tube label
Quality Assurance: ~ 90% by SDS-PAGE
Storage: Store at -80°C; avoid multiple freeze-thaw cycles
PDF Data Sheet: PDF DatasheetMSDS
NCBI RefSeq: NM_004993.5
Image(s): Images:
(Click image to enlarge)

Coomassie-stained SDS-PAGE
Lane 1: Molecular weight markers
Lane 2: 5 µg purified GST-Ataxin3(Q22)
Shipping Method: Dry ice shipping
References: 1. Tzvetkov N, et al. (2007) Biol. Chem. 388:973-978
2. Li F, et al. (2002) J. Biol. Chem. 277:45004-45012
3. Winborn BJ, et al. (2008) J Biol Chem. 26;283(39):26436-43

Details

Ataxin3 is a Machado-Josephine domain-containing deubiquitinating enzyme. Machado–Joseph disease (MJD) is a neurodegenerative disorder caused by polyQ expansion in ataxin-3. Ataxin3 is involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates.

Images:
(Click image to enlarge)

Coomassie-stained SDS-PAGE
Lane 1: Molecular weight markers
Lane 2: 5 µg purified GST-Ataxin3(Q22)